Beilstein J. Org. Chem.2014,10, 1808–1816, doi:10.3762/bjoc.10.190
, Japan 10.3762/bjoc.10.190 Abstract Macroscopic gelatinous colonies of freshwater cyanobacterium Aphanothece sacrum, a luxury ingredient for Japanese cuisine, were found to contain a new oxylipin-derived macrolide, sacrolideA (1), as an antimicrobial component. The configuration of two chiral centers
restaurants or for personal consumption.
Keywords: Aphanothece sacrum; cyanobacterium; food intoxication; natural products; sacrolideA; suizenji-nori; Introduction
Cyanobacteria continue to be core sources for bioactive secondary metabolites [1][2], and their significance in drug discovery has increased
fractionation resulted in the discovery of a new macrolactonic oxylipin, sacrolideA (1, Figure 1).
Results and Discussion
A. sacrum (500 g) was extracted with EtOH, and the combined extract was fractionated by solvent partitioning into n-hexane-, 10% aqueous MeOH-, 1-BuOH-, and water-soluble fractions